Until recently, many researches have investigated the relationship between strategic orientation and company performance . Strategic orientation is an important and extensive field in business management literature. The strategic activities of the company can describe the general meaning of the strategic orientation that directly affects the performance of the company's superior performance. The present study is an analysis of the impact of strategic orientations on the implementation of green supply chain management practices and sustainable performance in Yazd Industrial Estate companies. In this research, the statistical population is 300 employees of Yazd Industrial City companies, using the Cochran formula, the final sample number is 168 people, after distributing the questionnaires, 150 questionnaires were collected. In this research, structural equation modeling using PLS and SPSS software was used. The results show that green entrepreneurship orientation has a significant impact on market orientation, green supply chain management practices, and knowledge management orientation. Also, knowledge management orientation has a significant impact on green supply chain management practices, and green entrepreneurship orientation has an impact on green supply chain management practices through knowledge management orientation. The strategic activities of the company can describe the general meaning of the strategic orientation that directly affects the performance of the company's superior performance.